Holders AZ Alkmaar and 18-time winners Ajax survived scares to progress in the KNVB Beker with 4-1 and 4-2 wins.
PSV Eindhoven slipped to their first Eredivisie defeat of the season at AZ Alkmaar, while Ajax thrashed Go Ahead Eagles.
PSV Eindhoven stunned Ajax as they routed the defending champions 4-0 to climb to the top of the Eredivisie standings.
Three men were sent off as Heerenveen beat FC Groningen 4-2, while struggling Feyenoord salvaged a 3-3 draw at Nijmegen.
PEC Zwolle face the stiffest test of their season as they visit reigning Eredivisie champions Ajax on Saturday.
PEC Zwolle's 100 per cent winning start to the Eredivisie season ended after they drew 1-1 at home to FC Utrecht.
Feyenoord won 3-1 against NAC Breda while Utrecht secured all three points by beating AZ Alkmaar 2-0.
Marco van Basten will put his past with Ajax to one side when the champions visit the Abe Lenstra Stadion.
Kolbeinn Sigthorsson scored twice as Ajax beat Feyenoord to leave the side looking for their first points of the season.
Feyenoord will do everything possible to make sure Samuel Armenteros is available for their Eredivisie clash with Ajax.
Feyenoord lost 4-1 to FC Twente while Ajax went down 3-2 to AZ Alkmaar in Sunday's Eredivisie action.
Ajax's Viktor Fischer is delighted at the way the Eredivisie champions' coach Frank de Boer encourages him to play.
Sky Sports understands former Tottenham winger David Bentley is a target for Espanyol and FC Utrecht.
Feyenoord lose 2-1 at PEC Zwolle while Vitesse Arnhem win 3-1 against Heracles Almelo .
Sky Sports understands that a number of English clubs have joined the chase for Utrecht striker Jacob Mulenga.
Ajax have completed the signing of Holland Under-21 defender Mike van der Hoorn for an undisclosed fee from FC Utrecht.
Wigan are lining up a move for FC Utrecht striker Jacob Mulenga, Sky Sports understands.
Sky Sports understands that Nottingham Forest have lodged a bid for FC Utrecht striker Jacob Mulenga.
AZ Alkmaar have completed the signing of defender Jan Wuytens on a free transfer from Eredivisie rivals FC Utrecht.
Go Ahead Eagles ended their exile from the Eredivisie as they completed a 3-1 aggregate win over Volendam.